sysmex reference ranges

2012 Dec;34(6):566-76. doi: 10.1111/j.1751-553X.2012.01434.x. All XNs complete blood counts (CBC) include nucleated red blood cell (NRBC) counts automatically, to levels as low as 1/1000 WBC. This SEED article explains how reference ranges are defined and how they can be obtained in the lab. The procedure to examine the suitability for reference values that were determined elsewhere is explained as well. Currently, there are several scientific publications that provide information about the reference ranges for Sysmex analysers (see table below). A proportion of this can be realised by having the right technologies and IT systems in place and then applying them in the right way. If three to four samples are outside the reference range, a further 20 new samples must be taken and measured. Additionally, RET provides information on hypo- and hyperchromic red blood cells andfragmentocytes. This SEED article explains how reference ranges File size: 179 KB. For any clinical laboratory analysis, reliable and accurate reference intervals are essential to correctly interpret the test results. Clinic & Laboratory. 2013 Apr;35(2):193-9. doi: 10.1111/ijlh.12023. File size: 179 KB. Alongside the pure reticulocyte count, the XN-Series RET application provides reticulocyte fractions (IRF, LFR, MFR, HFR) that reflect maturity stages and therefore erythropoietic activity, and additional information on the quality of newly formed red blood cells by reporting the degree of reticulocyte haemoglobinisation (RET-He). This SEED article explains how reference ranges are defined and how they can be obtained in the lab. <>/Metadata 881 0 R/ViewerPreferences 882 0 R>> Labs are looking to reduce the paper trail and better utilise their LIS to seamlessly manage the assignment of tests within and between different laboratory locations, as well as the tracking of specimens that have to be transported within the network. Leverage your professional network, and get hired. Comparison between optical microscopy and the Sysmex XN-3000 for schistocyte determination in patients suspected of having schistocytosis. This novel approach is not only a useful adjunct to the use of traditional direct methods, but also has a number of advantages such as basing the outcomes on the analytical and pre-analytical procedures in use, the ability to address a wide range of populations, especially the population served by the laboratory, and, importantly, the relative ease of use and far lower costs. In this opinion paper, the IFCC C-RIDL encourages laboratories to use indirect methods to evaluate their reference intervals in use, to estimate new reference intervals and to publish and share their results in appropriate detail and also to continue the search for new and improved techniques for the process. This SEED article explains how reference ranges are defined and how they can be obtained in the lab. If not more than two of the 20 samples are outside this range, it may be used. The RefVal program. Sysmex Cellspotting. Because the analyser requires only 88L per analysis, you can reduce the sample size. Normally, the WPC analysis is triggered by a special rule set for reflex testing after analysis in the CBC+DIFF mode. Accordingly, Sysmex is very frequently asked about reference ranges for haematology parameters. For any clinical laboratory analysis, reliable and accurate reference intervals are essential to correctly interpret the test results. Adopting a published reference range without validation is not permissible and can even be dangerous for patients. And these clearly need different treatments. WebSysmex offers laboratories a full range of haematology platforms with a depth of clinical focused haematological parameters. If three to four samples are outside the reference range, a further 20 new samples must be taken and measured. https://pubmed.ncbi.nlm.nih.gov/29672266/. 1311 0 obj <>stream Technology can also assist with allocating work where there is pressure on qualified staff by allowing laboratories to easily reallocate tests and manage workload. FOIA Sysmex very frequently receives requests for reference ranges for the CBC parameters. Our logo represents the Sysmex Way. XN White blood cell differential, or XN-DIFF. If three to four samples are outside the reference range, a further 20 new samples must be taken and measured. In this opinion paper, the IFCC C-RIDL encourages laboratories to use indirect methods to evaluate their reference intervals in use, to estimate new reference intervals and to publish and share their results in appropriate detail and also to continue the search for new and improved techniques for the process. New Sysmex America jobs added daily. Reference ranges are essential for allowing conclusions on patients results. WebHaematological reference ranges are affected by several variables such as sex, race, altitude ( in case of red blood cell parameters ), etc. You can decrease your TAT since there is no further need for additional platelet enumeration either by platelet immunoflow cytometry or chamber counting. The indirect approach to determine reference intervals refers to a statistical analysis of already existing results from specimens which were collected for routine purposes (for example, samples collected for screening, diagnostic or monitoring purposes). If three to four samples are outside the reference range, a further 20 new samples must be taken and measured. To do this, the International Federation of Clinical Chemistry (IFCC) suggests the following procedure [1]: Twenty local reference samples are taken and compared with the reference range published elsewhere. (2004): The IFCC recommendation on estimation of reference intervals. 2015 Sep-Oct;73(5):547-56. doi: 10.1684/abc.2015.1073. WebFEMALE REFERENCE RANGES FOR SYSMEX INSTRUMENT . %PDF-1.7 You can select an automated body fluid mode as an option, dedicated to analysing cerebrospinal fluid (CSF), synovial, and serous (e.g. If not more than two of the 20 samples are outside this range, it may be used. If three to four samples are outside the reference range, a further 20 new samples must be taken and measured. If not more than two of these 20 samples are outside the range, it may be used. The mean SD was 0.14 0.35% and the median was 0% (95% confidence interval of the mean: 0.12-0.16%). (2018): Indirect methods for reference interval determination review and recommendations. This ensures a reliable white blood cell count, even at high NRBC concentrations. Company reviews. CK19 is an epithelial cell marker and is normally not present in lymph node tissue. To do this, the International Federation of Clinical Chemistry (IFCC) suggests the following procedure [1]: Twenty local reference samples are taken and compared with the reference range published elsewhere. Critically, you can also use the Sysmex RET count to identify what is really going on in clinical conditions like anaemia. 0 Act faster. This also means that published reference ranges from older analyser models have to be validated before they may be used with newer ones. In this opinion paper, the IFCC C-RIDL encourages laboratories to use indirect methods to evaluate their reference intervals in use, to estimate new reference intervals and to publish and share their results in appropriate detail and also to continue the search for new and improved techniques for the process. WebOSNA One Step Nucleic Acid Amplification is an automated molecular diagnostic assay that analyses the entire lymph node tissue. Hantaweepant C, Sasijareonrat N, Chutvanichkul B, Karaketklang K, Chinthammitr Y. Critically, you can also use the Sysmex RET count to identify what is really going on in clinical conditions like anaemia. Anaemia is a symptom of various clinical disorders yet often underestimated as a functional disorder of red blood cells. And it provides information on microcytes and macrocytes in addition to the red blood cell count. Clin Chem Lab Med 42: 710714. Epub 2012 Nov 8. [1] Solberg HE et al. While we are glad to provide you with a selection of literature, we would like to point out that reference ranges from different studies are only conditionally transferable, depending on the age, gender, ethnicity, etc. Clinic & Laboratory. https://pubmed.ncbi.nlm.nih.gov/29672266/. Without sample pre-treatment, a special automatically activated counting sequence provides a precise total count of nucleated cells (TNC). Our comprehensive line of flow cytometry products includes analyzers (CyFlow Cube and CyFlow Space), consumables (CellTrics filters) and reagents (CyFlow monoclonal The XN delivers this high sensitivity thanks to the special shape-recognition of the sub-population clusters. OSNA. If three to four samples are outside the reference range, a further 20 new samples must be taken and measured. This novel approach is not only a useful adjunct to the use of traditional direct methods, but also has a number of advantages such as basing the outcomes on the analytical and pre-analytical procedures in use, the ability to address a wide range of populations, especially the population served by the laboratory, and, importantly, the relative ease of use and far lower costs. Conclusion: Bethesda, MD 20894, Web Policies [1] Solberg HE et al. The rationale behind the study was the lack of reference intervals for the XN analyzer cell population data (CPD) and functional parameters. Copyright Sysmex Europe SE. AGE 0 - 2 Weeks 2 Weeks - 1 Months 1 Month - 2 Months 2 Vindt u niet wat u zocht of belt u liever? If not more than two of these 20 samples are outside the range, it may be used. Early CCLM, 57 (1), 20-29 Free online: https://pubmed.ncbi.nlm.nih.gov/29672266/. Scientific Calendar. This SEED article explains how reference ranges are defined and how they can be obtained in the lab. CCLM, 57 (1), 20-29 Free online: https://pubmed.ncbi.nlm.nih.gov/29672266/. An official website of the United States government. This SEED article explains how reference ranges The lamp intensity automatically adjusts to sample turbidity, which means all samples are properly analysed with constant high quality results. Adopting a published reference range without validation is not permissible and can even be dangerous for patients. Part II: white blood cells, red blood cells, haemoglobin, red cell indices and reticulocytes. [2] Jones GRD et al. The adoption of clinician electronic order requests also helps standardise the pre-analytical phase. Sysmex Parameters. The reference ranges that are currently in use in Zimbabwe were adopted from other countries and refer mainly to Caucasian subjects. WebReviews from Sysmex America employees in Boston, MA about Job Security & Advancement. All rights reserved. The rationale behind the study was the lack of reference intervals for the XN analyzer cell population data (CPD) and functional parameters. Available is the BB mode on XN-1000 and XN-2000 analysers, equipped with a RET and PLT-F channel. Currently, there are several scientific publications available that provide information about reference ranges for Sysmex analysers. WebSysmex has been providing innovative technology solutions to medical laboratories for over fifty years. 2022 Apr 27;17(4):e0267638. In addition to a sophisticated multi-lab LIS, these are essential to achieve standardisation and integrated information systems http://www.papsociety.org/accutane-isotretinoin/. How- Its suitability as a reference must be examined in every case. Clin Chem Lab Med 42: 710714. Job Title. The CA-101 uses turbo-densitometry and combines the best of both mechanical and optical detection principles. [2] Jones GRD et al. Contacteer ons dan rechtstreeks hier. Tecnologia. This is particularly useful if your laboratory handles a large number of abnormal samples, such as those from oncology or haematology wards. of the patient population in question. 8600 Rockville Pike These studies were performed on a variety of Sysmex haematology analyser models and the reference ranges evidently differ according to the populations involved. For over 50 years, we have actively set new standards and driven innovation in haematology and our other areas of expertise. Sysmex Educational Enhancement and Development, An alphabetical listing of scientific terms, SEED: Reference ranges and what Sysmex can offer. Critically, you can also use the Sysmex RET count to identify what is really going on in clinical conditions like anaemia. The International Federation of Clinical Chemistry (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) recently published an opinion paper about indirect methods for reference interval determination [2]. FRC counts may be of interest as they may reflect schistocyte counts measured on a stained peripheral blood smear observed under the microscope. Red and white blood cell morphology characterization and hands-on time analysis by the digital cell imaging analyzer DI-60. Samples with a low white blood cell concentration can be re-measured automatically in the special low WBC mode. CCLM, 57 (1), 20-29 Free online: https://pubmed.ncbi.nlm.nih.gov/29672266/. It automatically calculates the reticulocyte production index (RPI). The indirect approach to determine reference intervals refers to a statistical analysis of already existing results from specimens which were collected for routine purposes (for example, samples collected for screening, diagnostic or monitoring purposes). For more information click here: Perform the quality control of your blood products. Among the number of reported benefits that can be achieved with electronic orders, the lab analytical phase benefits from highly accurate, quality test requests. If not more than two of the 20 samples are outside this range, it may be used. hbbd```b``@$ QfHD>[M)02$EA ^'b@>&FfiBg Sy This produces reliable results for all your parameters, including the differential, through an extended counting sequence. The RefVal program. Release: (Sysmex J Int. sharing sensitive information, make sure youre on a federal It is non-reactive for hepatitis B surface antigen, hepatitis C virus (HCV) and HIV1/HIV2 anti-body using techniques specified by the FDA. The alternative is then a new survey or validation of another, different reference range. XN Complete blood count, or XN-CBC. Consolidation of the data, for instance in a centralised clinical data repository (CDR), reduces complexity and clinical risk by providing a standardized reporting method across multiple facilities. [2] Jones GRD et al. Anaemia is a symptom of various clinical disorders yet often underestimated as a functional disorder of red blood cells. The International Federation of Clinical Chemistry (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) recently published an opinion paper about indirect methods for reference interval determination [2]. endstream endobj 1269 0 obj <. xk-q` gnc/hd!`"%N bsuUYd|?~7_}|?o?__~?|~O~QwSo>/}]nz?]?~l~o>?~?jK/4m67azy3=f[jvFOOOo?{>oiK*C) ~XninxmX"1g4.i}Z694vqU*Ye}Cmucw^T?[dawC}l^/o=ge[?&?jc?ud}RJTho{?#e?+us>u[jlq6$; Clin Chem Lab Med 42: 710714. The reaction is based on rapid nucleic acid amplification technology (RT-LAMP*) to quantify Cytokeratin 19 (CK19) mRNA expression. All rights reserved. Technologies. [2] Jones GRD et al. WebThe XN-9000 is one of the latest models from the Sysmex series of analysers. Act faster. 1 0 obj An alphabetical listing of scientific terms, EMEA Collaboration & Leadership Principles. Were now among Europes top laboratory diagnostics and healthcare companies, and the global leader for haematology diagnostics and service. Copyright Sysmex Europe SE. Healthcare agencies may consolidate their capabilities around one reference laboratory, or establish a regional network of tiered laboratory services, where laboratories within the network offer different levels of service or specialise in a variety of tests. It avoids interferences from non-cellular particles such as lyse-resistant RBC or lipids. This can enable consistency for the clinical interpretation regardless of the actual lab that performed the tests. Know more. The procedure to examine the suitability for reference values that were determined elsewhere is explained as well. The indirect approach to determine reference intervals refers to a statistical analysis of already existing results from specimens which were collected for routine purposes (for example, samples collected for screening, diagnostic or monitoring purposes). SEED: Reference ranges and what Sysmex can offer. Summary of Consolidated Financial Results PLoS One. Would you like email updates of new search results? %%EOF Privacy policy. Decide with confidence. This novel approach is not only a useful adjunct to the use of traditional direct methods, but also has a number of advantages such as basing the outcomes on the analytical and pre-analytical procedures in use, the ability to address a wide range of populations, especially the population served by the laboratory, and, importantly, the relative ease of use and far lower costs. Fragmented red blood cells automated measurement is a useful parameter to exclude schistocytes on the blood film. Fragmented red cells reference range (Sysmex XN() automated blood cell counter). Europe | EN. Our products are needed. Methods Fresh fasting blood samples from 18,484 participants in the Dutch Lifelines study were analyzed using two (2004): The IFCC recommendation on estimation of reference intervals. Clinic & Laboratory. With dedicated scientific and industrial applications, our systems and optimised reagents kits cover everything from A shared LIS also allows better collaboration for report validation and sign-off steps when required with reassignment of work managed through the single LIS. All rights reserved. And thanks to auto-correction for NRBC, you know your white blood cell values in neonate samples are going to be correct. Currently, there are several scientific publications available that provide information about reference ranges for Sysmex analysers. By assigning certain tests to specific facilities, regional health organisations are able to reduce the associated overheads. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Lesesve JF, Daigney A, Henry S, Speyer E. Ann Biol Clin (Paris). The XNs WPC flagging helps diagnose both myeloid and lymphatic diseases with genuine diagnostic validity. If this appeals to you, come and join us. While we are glad to provide you with a selection of literature, we would like to point out that reference ranges from different studies are only conditionally transferable, depending on the age, gender, ethnicity, etc. If not more than 2 of the 20 samples are outside this range, it can be used. If 3 - 4 samples are outside the reference range, a further 20 new samples must be taken. Conditions of Sales eCollection 2020 Mar. Evaluation of fragmented red cell (FRC) counting using Sysmex XE-5000 - does hypochromia play a role? (2018): Indirect methods for reference interval determination review and recommendations. For this reason, the individuals who served as the basis for the selected reference range should be as similar as possible to the patient population to whom the reference range is to be applied. The company was renamed Sysmex Corporation in 1998 taking advantage of brand recognition of their XN-CHECK level 2 covers the normal range, XN-CHECK level 1 is used for the abnormal low range and XN-CHECK level 3 monitors the abnormal high rage. A new survey or the validation of another, different reference range would be the next options. Labs within a regional network often share a single instance of an enterprise-wide LIS providing the foundation to standardise pre-analytical, analytical and post-analytical stages of the laboratory workflow across their network. This also means that published reference ranges from older analyser models have to be validated before they may be used with newer ones. Haemoglobin, red blood cells, cell count and indices, reticulocytes]. WebWelkom bij Sysmex. If in the initial verification five or more samples or more than two of a repeated set of samples are outside the published range, it is not suitable for use as a reference for local patients. Go back to Homepage %PDF-1.6 % A new survey or the validation of another, different reference range would be the next options. If in the initial verification, 5 or more samples, or more than 2 of a repeated set of samples, are outside the published range, it is not suitable for use as a reference for local patients. Sysmex Educational Enhancement and Development April 2015 The actual meaning of reference ranges and their purpose File type: pdf. (2018): Indirect methods for reference interval determination review and recommendations. If not more than two of these 20 samples are outside the range, it may be used. WebSysmex's integrated solutions. Sysmex Receives Manufacturing and Marketing Approval for an Assay Kit to Identify Amyloid Beta (A) Accumulation in the Brain, a Cause of Alzheimer's Disease, Using a Small Amount of Blood. It matters because the immature platelet fraction, for example, indicates whether the cause of thrombocytopenia is in the bone marrow or peripheral blood. For this reason, the individuals who served as the basis for the selected reference range should be as similar as possible to the patient population to whom the reference range is to be applied. Introduction: Careers. Decide with confidence. If not more than two of these 20 samples are outside the range, it may be used. WebReference ranges. endobj Since as explained above there are differences between haematological reference ranges determined from different populations, the information in the table below may facilitate the selection of an appropriate reference range as an initial point for validation. https://pubmed.ncbi.nlm.nih.gov/29672266/. Since as explained above there are differences between haematological reference ranges from different populations, the information in the table may facilitate the selection of an appropriate reference range as an initial point for validation. WebTodays top 1 Sysmex America jobs in Boston, Massachusetts, United States. Sysmex South Africa (Pty) Ltd. Fernridge Office Park, Block 1, Randburg 2194 +27 (11) 329 94 80. [email protected]. WebSEED: Reference ranges and what Sysmex can offer Reference ranges are essential for allowing conclusions on patients results. There are many important aspects that are relevant to todays laboratories looking to achieve standardisation. Act faster. pleural, CAPD or ascites) fluids. My Sysmex - customer portal Reference ranges. Sign in. Zandecki M, Genevieve F, Gerard J, Godon A. Int J Lab Hematol. 2007 Feb;29(1):21-41. doi: 10.1111/j.1365-2257.2006.00871.x. White blood cells. WebHaematological reference ranges are affected by several variables such as sex, race, altitude ( in case of red blood cell parameters ), etc. All rights reserved. It is of particular interest for samples with detected abnormal WBC populations, especially when they contain blasts or abnormal lymphocytes. <> This matters. In this opinion paper, the IFCC C-RIDL encourages laboratories to use indirect methods to evaluate their reference intervals in use, to estimate new reference intervals and to publish and share their results in appropriate detail and also to continue the search for new and improved techniques for the process. All rights reserved. official website and that any information you provide is encrypted HHS Vulnerability Disclosure, Help AGE 0 - 2 Weeks 2 Weeks - 1 Months 1 Month - 2 Months 2 Months - 6 Months 6 Months - 2 Years 2 Years - 6 Years 6 Years - 12 Years 12 Years - 18 Years 18 Years - 150 Years UNITS This also means that published reference ranges from older analyser models have to be validated before they may be used with newer ones. Know more. Its suitability as a reference must be examined in every case. Clinic & Laboratory. Material, methods and results: We aimed to establish a reference range for FRCs based on 1366 WebObjectives Our aim was to derive reference intervals for all Sysmex XN hematology analyzer parameters. CCLM, 57 (1), 20-29 Free online: https://pubmed.ncbi.nlm.nih.gov/29672266/. In fact, the XNs dedicated fluorescence-optical analysis is comparable to the reference method even with low cell concentrations. And immature platelet counts are delivered by a fast and fully automated method, with no interference by fragmented red cells or broken white blood cells. [Automated hematology analysers and spurious counts Part 3. Upload your resume. Clnica e laboratrio. WebSysmex Corporation is a Japanese company headquartered in Kobe that is engaged in the health care business. The reticulocyte count using our proprietary fluorescence flow cytometry methodology is recognised for its accuracy around the world. The mean SD was 0.14 0.35% and the median was 0% (95% confidence interval of the mean: 0.12-0.16%). You can therefore offer high specificity in this specialised area. XN Fluorescence Find jobs. government site. The site is secure. The WPC channels high specificity also helps you cut the number of manual smears after screening for WBC abnormalities in the CBC+DIFF profile. The indirect approach to determine reference intervals refers to a statistical analysis of already existing results from specimens which were collected for routine purposes (for example, samples collected for screening, diagnostic or monitoring purposes). Act faster. Once you start thrombocytopenia treatment, its now also easier to monitor. These studies were performed on a variety of Sysmex haematology analyser models and the reference ranges evidently differ according to the populations involved. Sysmex Parameters. Lab systems are interfaced to a wide variety of external systems and multilab solution can simplify and standardize a solution especially when combined with message and coding standards such as HL7, LOINC, SNOMED, and patient and health provider identifiers. hb```f``k B,@Q,>00] cqVy~,xO_MP8XzKE:yX3V3,bgG'G'..]sg2;h* `d`>H3@ y' 1294 0 obj <>/Filter/FlateDecode/ID[<29006EE26F56164CB5DA2F1958E9E98E>]/Index[1268 44]/Info 1267 0 R/Length 126/Prev 317638/Root 1269 0 R/Size 1312/Type/XRef/W[1 3 1]>>stream Decide with confidence. Accordingly, Sysmex is very frequently asked about reference ranges for haematology parameters. Spurious counts and spurious results on haematology analysers: a review. Material, methods and results: 2 0 obj If only 20L of blood are available, the additional pre-diluted mode means you can receive full differential results from capillary samples too. If not more than two of the 20 samples are outside this range, it may be used. WebSysmex Reference Ranges Preferred Lab Partners RBC (x106/mcl) HGB (g/dl) HCT (%) MCV (fL) MCH (pg) MCHC (g/dl) RDW (%) PLT (x103/mcl) MPV (fL) Age Reference Ranges 0-14 Our PLT-F method offers a five-fold counting volume for PLT compared to the routine measurement. Sysmex Educational Enhancement and Development, An alphabetical listing of scientific terms, Point-of-care and essential healthcare testing, fCAL for IBS/IBD differential diagnosis (CALiaGold), SEED: Reference ranges and what Sysmex can offer. }iT>j4z'VLu|JT&\ZVNkrtY[g6s\_yd}uisMLZmth%>^(M4{\%~mresT2q_nec*Z7++O?\Z?A-mG7j0}4_Ns2+at ^glG,et}4[XFG=J2T+iNe;Zdm7sAw8T8";^P-2`SbSjvx8' !Z6fmO; 3gbm65dK3-ZQ;Adzz?XnGA8p& 8}9BG5c:OmNha2 nwdr;3-\8Ymc@+}?NmwNlw !N>"-@j}ds!wzRb0G.? eCollection 2022. "xh.oiTn_/V&MbY|yMe>|[oq S9n qSr@k4W7h`+CCLX=fuG00e^-eY)[ Accordingly, Sysmex is very frequently asked about reference ranges for haematology parameters. [1] Solberg HE et al. endobj WebXN-450 Compact 6-part differential analyser Throughput of 70 samples per hour Single sample analysis in closed mode Fully integrated IPU including LCD colour touchscreen Only 25 L aspiration volume in whole blood mode More than just CBC + DIFF added clinical values available Best-in-class diagnostics tailored to small and mid-sized laboratories WebZimbabwean and European reference ranges and similarities between Zimbabwean and reference ranges from other African studies. Please enable it to take advantage of the complete set of features! https://pubmed.ncbi.nlm.nih.gov/29672266/, British, pregnant women (antenatal and postnatal). For any clinical laboratory analysis, reliable and accurate reference intervals are essential to correctly interpret the test results. Web54 Reference intervals and orienting ranges for Clinical Chemistry and Laboratory Medicine in fetuses, newborn and adolescents D. Klarmann, G. Hintereder, L. Thomas The reference intervals, orienting ranges and decision limits of laboratory investigations provide physicians with objective data for clinical interpretation of a laboratory result. WBC values are provided automatically if NRBC are present. WebXN CHECK is available in three different concentrations. Since as explained above there are differences between haematological reference ranges determined from different populations, the information in the table below may facilitate the selection of an appropriate reference range as an initial point for validation. XN Reticulocytes, or RET. These studies were performed on a variety of Sysmex haematology analyser models and the reference ranges evidently differ according to the populations involved.